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Coronin 1-A

Rabbit Polyclonal Antibody

PRODUCT #: 40-1267

 

DESCRIPTION: Coronin was originally discovered in Dictyostelium, where it was found to be involved in the chemotactic response of these ameboid cells. The name derives from the fact that the protein is localized at the leading edge or crown of these highly motile cells. Coronin can be used to study the leading edges of neutrophils. Also, this antibody is an important marker of the CNS cells microglia, microglial activation is seen in response to a wide variety of damage and disease states, including ALS, Alzheimer's disease and responses to brain tumors. Since coronin is a constitutive component of microglia, the coronin antibody can be used to study both quiescent and activated microglia.
   
SPECIES CROSS-REACTIVITY: Bovine, human, mouse, rat

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/200-1,000)
WB (1/5,000)
   
SOURCE: Rabbits were immunized with full-length human coronin 1-A expressed in E. coli.
   
FORM / STORAGE: 0.1 ml with 50% glycerol, 0.01% sodium azide. Store at -20º C. Avoid multiple freeze/thaw cycles. Immunoglobulin isotype is IgG1.
 
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.