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GIPC

Rabbit Polyclonal Antibody

PRODUCT #: 25-6792

 

DESCRIPTION: GIPC is a PDZ-domain-containing adapter protein. GIPC binds to proteins that have at their C-termini a conserved type I PDZ-binding site (S/T)-X-(V/A). GIPC’s PDZ domain can bind multiple members of the low-density lipoprotein receptor (LDLR) family (e.g megalin), kinase receptors, G-protein coupled receptors and cell-surface adhesion proteins.. GIPC also binds directly to myosin-VI (make this myosin-VI be a link to the other antibody). GIPC is found on uncoated vesicles along with myosin-VI in all cell types examined. There is also evidence for a role for GIPC in trafficking of transmembrane proteins through the Golgi stacks. Other names for GIPC include: synectin, SEMCAP-1, GLUT1CBP.

 

SPECIES CROSS-REACTIVITY:

Human, primate, rat
 
APPLICATIONS/DILUTIONS:

IF (5-10 ug/ml)
IP (1-10 ug/reaction)
WB (0.1-0.5 ug/ml)
 
SOURCE:

Rabbits were immunized with amino acids 100-333 from rat GIPC protein.
 
FORM/STORAGE:

50 ug (0.5 mg/ml) of affinity purified IgG with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.  Store at -20º C.  Avoid multiple freeze/thaw cycles.

 

References:
Hasson, T. and M. S. Mooseker (1994). Journal of Cell Biology 127:425-440. Hasson, T. et al. (1997), Journal of Cell Biology 137:1287-1307. Dance, A. L. et al. (2004), Traffic 5:798-813.

 

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.