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Myosin-VI

Rabbit Polyclonal Antibody

PRODUCT #: 25-6791

 

DESCRIPTION: Myosin-VI is one of the unconventional members of the myosin molecular motor superfamily. The protein has broad tissue expression and has been implicated in endocytosis at both the clathrin-coated and uncoated stages.  Regulation of myosin-6 transport has been shown to involve adaptor proteins including GIPC, which contains a PDZ-domain for uncoated vesicle recruitment and Dab2 for clathrin-coated vesicle association. In hair cells of the inner ear, absence of functional myosin-VI protein leads to cell death and deafness.
 

SPECIES CROSS-REACTIVITY:

Broad
 

APPLICATIONS/DILUTIONS:

IF (5-10 ug/ml)
WB (0.5-1.0 ug/ml
 

SOURCE:

Rabbits were immunized with amino acids 1049-1254 from the tail region of porcine myosin-VI.
 

FORM/STORAGE:

50 ug (0.5 mg/ml) of affinity purified IgG with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.  Store at -20º C.  Avoid multiple freeze/thaw cycles.
 

References:
Hasson, T. and M. S. Mooseker (1994). Journal of Cell Biology 127:425-440.
Hasson, T. et al. (1997), Journal of Cell Biology 137:1287-1307.
 

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.