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Neurofilament, NF- L (Clone 7D1)

Mouse Monoclonal Antibody

PRODUCT #: 40-1279

 

 

DESCRIPTION: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-L is the neurofilament light or low molecular weight polypeptide and runs on SDS-PAGE gels at about 68kDa. Antibodies to NF-L are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-L antibody can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Amyotrophic lateral sclerosis (ALS) otherwise known as Lou Gehrig's disease and Alzheimer's disease. Mutations in the protein coding region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.
   
SPECIES CROSS-REACTIVITY: Mammalian - broad

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/100 to 1/500)
WB (1/1,000 to 1/5,000)
   
SOURCE: Mice were immunized with pig spinal cord neurofilament NF-H and NF-L .
   
FORM/STORAGE: 0.1 ml with 50% glycerol, 0.01% sodium azide. 
Store at -20º C.  Avoid multiple freeze/thaw cycles.
   
Reference: Mersiyanova IV, et al.  Am. J. Hum. Genet. 67:37-46, 2000.
   
 
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.