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Neurofilament, NF-H (Clone AH1)

Mouse Monoclonal Antibody

PRODUCT #: 40-1275

 

DESCRIPTION: Neurofilaments are the 10nm or intermediate filament proteins found specifically in neurons, and are composed predominantly of three major proteins called NF-L, NF-M and NF-H. NF-H is the neurofilament high or heavy molecular weight polypeptide and runs on SDS-PAGE gels at 200-220 kDa, with some variability across species boundaries. Antibodies to NF-H are useful for identifying neuronal cells and their processes in tissue sections and in tissue culture. NF-H antibodies can also be useful in the diagnostics of neurofilament accumulations seen in many neurological diseases, such as Amyotrophic Lateral Sclerosis (also known as Lou Gehrig's disease) and Alzheimer's disease. MCA-AH1 is one of numerous antibodies which reacts preferentially with the axonal phosphorylated forms of NF-H.
   
SPECIES CROSS-REACTIVITY: Bovine, human, mouse, rat

 

APPLICATIONS/DILUTIONS:        ICC/IF (1/200)
WB (1/1,000)
   
SOURCE: Mice were immunized with NF-H purified from bovine spinal cord.
   
FORM/ STORAGE: 0.1 ml with 50% glycerol, 0.01% sodium azide. Store at -20º C.  Avoid multiple freeze/thaw cycles. Immunoglobulin isotype is IgG1.
   
 
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.