| DESCRIPTION: PIN-1 is the peptidylprolyl cis/trans isomerase enzyme which is responsible for isomerizing the proline ring from the cis to the trans conformation. This enzyme is heavily upregulated in tumor cells, so that antibodies to this protein can be used as tumor markers. Pin-1 protein is concentrated in the nucleus in small punctate structures and is particularly obvious in tumor cells. |
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| SPECIES CROSS-REACTIVITY: |
Human, mouse, rat |
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| APPLICATIONS/DILUTIONS: |
ICC/IF (1/100-1/1,000)
WB (1/2,000) |
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| SOURCE: |
Chickens were immunized with full-length recombinant human Pin-1. |
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| FORM/STORAGE: |
0.1 ml with 50% glycerol, 0.01% sodium azide.
Store at -20º C. Avoid multiple freeze/thaw cycles. Immunoglobulin isotype is IgY. |
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| Reference: |
Lu KP, et al. Nature 380 544-547, (1996). |
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THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.
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