Saturday, October 21, 2017You are here Products / Antibodies / CELL SIGNALING
Print

Protein Tyrosine Phosphatase Mu (Clone SK15)

Mouse Monoclonal Antibody

PRODUCT #: 45-6792

 

DESCRIPTION: PTPµ (Protein tyrosine phosphatase mu) is a receptor type protein tyrosine phosphatase with a predicted molecular weight of 162 kDa that migrates in SDS-PAGE as a 200 kDa protein and undergoes a processing step to generate a functional phosphatase of ~100 kDa.  There are 13 potential N-glycosylation sites in the sequence.  The primary function of the protein appears to be to mediate cell aggregation.  The human gene has been mapped to chromosome 18pter-q11, a region that is frequently associated with abnormalities in cancers.  PTPµ has been shown to be highly expressed in the nervous system where it is found in a complex with N-cadherin and promotes neurite outgrowth.  In other studies, PTPµ has been shown to be expressed in vascular endothelial beds but not in the endocardium.  PTPµ has now been shown to be associated with E- and R-cadherins as well as with the aforementioned N-cadherin although earlier studies failed to demonstrate such associations.  Protein tyrosine phosphatases in general and PTPµ in particular may be important in regulating the adhesion and aggregation of cancer cells particularly in light of the observations that different cancers display differential expression of protein tyrosine phosphatases.


SPECIES CROSS-REACTIVITY:


Human
Negative for mouse and rat.
 


APPLICATIONS/DILUTIONS:


IP (1 ug/sample)
Western blot (2.5 ug/ml)
 


SOURCE:


Mice were immunized with human PTP Mu and fusing the splenocytes with Sp2/0 mouse myeloma cells.
 


FORM/STORAGE:


100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA. Store at -20º C. Avoid multiple freeze/thaw cycles.


THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.