|
DESCRIPTION:
Stearoyl-CoA desaturase (SCD) is a regulatory enzyme in lipogenesis. The SCD1 gene is tightly regulated by signals such as insulin, leptin, carbohydrate, fatty acids and temperature. The enzyme (mouse 355aa, rat 358aa; ~37 KDa) is constitutively expressed in adipose tissue and is induced in liver in response to fat free, high carbohydrate diet. The SCD-1 expression is higher in female than male mouse. The repression of RNA levels and enzyme activity of hepatic SCD-1 by Leptin has been shown to significantly reduce the triglyceride storage, VLDL production and therefore an increase in fatty acid oxidation. Inhibition of SCD-1 could be of benefit for treatment of obesity, hepatic steatosis and other metabolic disorders.
|
| SPECIES CROSS-REACTIVITY: |
Human, mouse |
APPLICATIONS/DILUTIONS:
|
WB (1:100-250)
ELISA (1-2000-5000)
|
| SOURCE: |
Mice were immunized with recombinant SCD1 protein. |
| FORM/STORAGE: |
50 ug (0.5 mg/ml affinity purified IgG2b in PBS with 50% glycerol, 1.0 mg/ml BSA and 0.01% sodium azide). Store at -20o C. Avoid multiple freeze/thaw cycles. |
|
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.
|