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c-ErbB2/Her2/c-Neu (Clone ORP185)

Mouse Monoclonal Antibody

PRODUCT #: 45-6805

 

DESCRIPTION: Amplification of the human protooncogene c-neu occurs in approximately 30% of breast carcinomas and the amplification may be a useful predictor of disease prognosis. Gene amplification and the resulting overexpression of protooncogene encoded proteins is thought to transform cells by chronically stimulating signal transduction pathways and in model systems overexpression of human c-neu induces cellular transformation. In the rat model system, a point mutation has been located within the transmembrane domain of the c-neu oncogene.

 

SPECIES CROSS-REACTIVITY:

Human
 

APPLICATIONS/DILUTIONS:

IF (2.5 ug/ml)
 

SOURCE:

Recombinant human cc-ErbB2/Her2/c-Neu protein. Epitope is known reside within the extracellular domain.
  

FORM/STORAGE:

100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA. Store at -20º C. Avoid multiple freeze/thaw cycles.

 

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS OR DIAGNOSTIC PROCEDURES.